The London Weight Loss Clinic

GLP-1 receptor agonists have revolutionised weight loss treatment, offering a medically-proven approach to sustainable weight management. In this comprehensive guide, we'll explore everything you need to know about these groundbreaking medications.

What Are GLP-1 Medications?

GLP-1 (Glucagon-Like Peptide-1) receptor agonists are a class of medications originally developed for type 2 diabetes that have shown remarkable efficacy for weight loss. These medications mimic a naturally occurring hormone in your body that regulates appetite, blood sugar, and digestion.

Common GLP-1 Medications:

Semaglutide (Wegovy, Ozempic, GLP-1 Oral Spray)
Tirzepatide (Mounjaro, GLP-1 Oral Spray)
Liraglutide (Saxenda, Victoza)

How Do GLP-1 Medications Work?

GLP-1 medications work through several interconnected mechanisms to promote weight loss:

1. Appetite Regulation

GLP-1 acts on receptors in the brain that control hunger and satiety. By enhancing these signals, you feel fuller with smaller portions and experience reduced cravings between meals.

2. Slowed Gastric Emptying

These medications slow the rate at which food leaves your stomach, leading to prolonged feelings of fullness and helping you eat less throughout the day.

3. Blood Sugar Control

GLP-1 medications help regulate blood sugar levels by stimulating insulin release when blood sugar is high and reducing glucagon secretion. This helps prevent energy crashes and reduces sugar cravings.

4. Metabolic Benefits

Beyond weight loss, GLP-1 medications have been shown to improve cardiovascular health markers, reduce inflammation, and may provide protective effects for the heart and kidneys.

Expected Results

Clinical trials have demonstrated impressive weight loss outcomes with GLP-1 medications:

Average weight loss of 15-20% of total body weight over 12-18 months
Sustained results with continued treatment and lifestyle support
Improved metabolic health including blood pressure, cholesterol, and blood sugar
Reduced cardiovascular risk demonstrated in long-term studies

Who Are GLP-1 Medications For?

GLP-1 medications are typically prescribed for adults who:

Have a BMI of 30 or greater (obesity), or
Have a BMI of 27 or greater (overweight) with at least one weight-related health condition
Have tried traditional weight loss methods without sustained success
Are committed to a comprehensive weight loss programme including lifestyle changes

Traditional Injections vs Oral Spray

While GLP-1 medications have traditionally been delivered via weekly subcutaneous injections, innovative formulations like our oral spray now offer needle-free alternatives:

Injectable Options

• Weekly administration
• Pre-filled pens
• Requires refrigeration
• Peak and trough levels

Oral Spray (Oral Spray)

• Daily sublingual administration
• No needles required
• No refrigeration needed
• More consistent blood levels

Starting GLP-1 Treatment

Beginning treatment with GLP-1 medications involves a careful, medically supervised process:

Medical Assessment: Comprehensive evaluation of your health history and weight loss goals
Prescription: Your doctor determines the appropriate medication and starting dose
Gradual Titration: Doses are slowly increased over weeks to minimise side effects
Ongoing Monitoring: Regular check-ins to assess progress and adjust treatment
Lifestyle Support: Nutrition guidance, coaching, and behavioural support

Ready to Explore GLP-1 Treatment?

Our expert medical team can help determine if GLP-1 medications are right for your weight loss journey. Take our free assessment or book a consultation today.

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