Starting Your First GLP-1 Medication: What to Expect

Starting a GLP-1 medication is a significant step in your weight loss journey. Proper preparation can help ensure a smooth start and set you up for success.

Before Your First Dose

• Medical Clearance: Ensure you've completed all required health assessments and have received clearance from your healthcare provider.
• Review Instructions: Carefully read all medication instructions, including storage requirements and injection technique.
• Plan Your Schedule: Choose a consistent day and time for your weekly injection that fits your routine.
• Stock Your Kitchen: Prepare protein-rich, easily digestible foods in case appetite changes occur.
• Set Realistic Expectations: Understand that weight loss is gradual and side effects may occur initially.

Your clinic should provide comprehensive training on injection technique, but don't hesitate to ask for a refresher if needed.

The first dose of GLP-1 medication is typically the lowest in the titration schedule. This gradual start helps your body adjust to the medication.

Immediate Effects (First 24-48 Hours)

• Appetite Changes: Many patients notice reduced hunger within 24-48 hours of their first dose.
• Mild Nausea: Some digestive discomfort is common as your body adjusts to slowed gastric emptying.
• Increased Fullness: You may feel satisfied with smaller portions than usual.
• Energy Levels: Some patients experience temporary fatigue as the body adapts.

First Week Experience

During the first week, your body is beginning to respond to the medication. You might experience:

• Gradual decrease in cravings for high-calorie foods
• Improved portion control at meals
• Possible mild digestive changes (constipation or loose stools)
• Reduced interest in snacking between meals

Remember, everyone's experience is different. Some patients notice dramatic changes immediately, while others experience more gradual effects.

Understanding the typical timeline for GLP-1 medications helps set realistic expectations and maintain motivation throughout your journey.

Week 1-4: Initial Phase

• Weight loss: 2-5 pounds typically
• Primary focus on adjusting to medication
• Appetite suppression begins
• Side effects most common during this period

Months 2-3: Acceleration Phase

• Weight loss: 1-2 pounds per week on average
• Dose titrations continuing
• Side effects generally improving
• Lifestyle changes becoming habitual

Months 4-6: Steady Progress

• Weight loss: 10-15% of starting weight by month 6 for many patients
• Reaching maintenance dose
• Establishing long-term eating patterns
• Integrating exercise routines

Beyond 6 Months

Continued weight loss is possible, with many patients achieving 15-22% total body weight reduction over 12-18 months. The rate of loss typically slows as you approach a healthier weight range.

Most side effects from GLP-1 medications are temporary and improve as your body adjusts. Here's how to manage common issues:

Nausea Management

• Eat smaller, more frequent meals
• Avoid lying down immediately after eating
• Choose bland, easily digestible foods initially
• Stay hydrated with small sips throughout the day
• Consider ginger tea or ginger supplements

Digestive Changes

• Constipation: Increase fiber gradually, stay hydrated, consider a stool softener
• Diarrhea: Avoid high-fat foods, eat slowly, stay hydrated with electrolytes
• Heartburn: Avoid trigger foods, don't eat close to bedtime, elevate head while sleeping

When to Contact Your Provider

Seek medical attention if you experience:

• Severe abdominal pain
• Persistent vomiting preventing hydration
• Signs of pancreatitis (severe upper abdominal pain radiating to back)
• Visual changes or severe headaches
• Signs of gallbladder problems (pain in upper right abdomen)

The first month sets the foundation for your entire GLP-1 journey. Follow these evidence-based strategies to maximise your results:

Nutrition Strategies

• Prioritize Protein: Aim for 25-30g protein per meal to preserve muscle mass
• Stay Hydrated: Drink 8-10 glasses of water daily
• Choose Nutrient-Dense Foods: Make every calorie count with whole foods
• Avoid Empty Calories: Limit alcohol, sugary drinks, and processed snacks
• Eat Slowly: Take 20-30 minutes per meal to recognise fullness signals

Lifestyle Habits

• Track Your Progress: Log weight, measurements, and non-scale victories
• Start Moving: Begin with gentle exercise like walking, gradually increasing intensity
• Get Adequate Sleep: Aim for 7-9 hours nightly to support weight loss
• Manage Stress: Practice relaxation techniques to avoid stress-eating
• Build Support: Connect with others on similar journeys

Monitoring & Communication

• Keep a symptom diary for the first month
• Note patterns in appetite, energy, and mood
• Take progress photos and measurements weekly
• Maintain regular contact with your healthcare team
• Don't hesitate to ask questions or report concerns

Remember, the first month is about establishing healthy patterns that will support your long-term success. Be patient with yourself and celebrate small victories along the way.