Mounjaro Dosage: Finding Your Optimal Dose
Medically Reviewed By
Dr. Rabih Wassel, MBBS, BSc, MSc, MRCS, MRCGP
Chief Medical Officer
Mounjaro (tirzepatide) offers a flexible dosing approach, ranging from 2.5mg to 15mg weekly. This comprehensive guide explains how to find your optimal dose, what to expect during dose escalation, and how to adjust treatment for maximum weight loss results.
Mounjaro Dosing Overview
Mounjaro is administered once weekly via subcutaneous injection. The dosing strategy involves gradual escalation to minimise side effects while maximising weight loss efficacy. Key points:
- Start at 2.5mg weekly for 4 weeks
- Increase dose every 4 weeks based on tolerance and response
- Maximum approved dose is 15mg weekly
- Many patients achieve excellent results at doses lower than the maximum
Starting Dose and Titration
| Weeks | Dose | Purpose |
|---|---|---|
| 1-4 | 2.5mg | Initial dose, body adaptation |
| 5-8 | 5mg | Appetite suppression increases |
| 9-12 | 7.5mg | Enhanced weight loss |
| 13-16 | 10mg | Significant results for many patients |
| 17-20 | 12.5mg | Near-maximum effect |
| 21+ | 15mg | Maximum approved dose |
Finding Your Optimal Dose
Not everyone needs the maximum 15mg dose. Your optimal dose depends on:
- Weight loss response: If you're achieving 1-2kg (2-4 pounds) per week, you may not need dose increases
- Side effect tolerance: Higher doses may cause more gastrointestinal effects
- Individual metabolism: Some people are more sensitive to tirzepatide
- Treatment goals: Your target weight and timeframe
Clinical Insight
In clinical trials, patients on 10mg and 15mg doses experienced similar weight loss outcomes (20-21% body weight). This suggests that 10mg may be sufficient for many individuals, potentially reducing cost and side effects.
Dr. Rabih Wassel
Chief Medical Officer • MBBS, BSc, MSc, MRCS, MRCGP
Dr. Rabih Wassel is a board-certified physician specializing in obesity medicine with over 15 years of experience in weight management and metabolic health.